Doktorsavhandlingar / Doctoral Theses - H7 (MedH)
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Recent submissions
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Biomarkers in hepatocellular carcinoma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-05-13)Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Globally in 2020, liver cancer were the seventh most common cancer form and the second most common form of cancer related death. Early HCCs are often ... -
Catheter ablation of atrial fibrillation : methods for improving outcome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-30)Introduction: The most common arrhythmia world-wide is atrial fibrillation (AF). The arrhythmia is diagnosed through an electrocardiogram (ECG). Patients with AF often experience symptoms including palpitations, dyspnoea, ... -
Exploring cannabinoids for indolent B-cell lymphomas
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-26)The overexpression of cannabinoid receptors is well described in several indolent lymphomas but the relevance of this finding is more uncertain. Our group has previously shown that mantle cell lymphoma (MCL)-derived cell ... -
Risk factors for colorectal cancer and the impact on life in lynch syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-23)Colorectal cancer (CRC) constitutes the third most common cancer in Sweden. Approximately 2-4% of CRC cases have a pathogenic variant in a gene known to cause an inherited risk of CRC. The most common hereditary CRC syndrome, ... -
Exploring T cell mediated immunotherapy against therapy resistant leukemic stem cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-19)The cancer stem cell (CSC) model suggests that cancers depend on continuous replenishment from rare and distinct CSCs, but their existence has been challenging to prove for many malignancies. The CSCs in myeloid leukemias, ... -
Exploring lipoprotein characteristics in human cardiometabolic disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-18)Background: Atherosclerosis underlies most cases of cardiovascular disease (CVD) which remains the principal cause of global mortality. CVD is significantly linked to cardiometabolic diseases such as diabetes and obesity. ... -
Cancer risk, autoimmune comorbidity and autoantibodies in primary sclerosing cholangitis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-05)Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease affecting the bile ducts primarily, and the liver parenchyma secondarily. The disease is progressive but highly variable between diseased. Some ... -
Immune cell-derived adipokines : role in white adipose tissue function and link to metabolic health
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-01-17)The white adipose tissue (WAT) is home to a vast array of immune cells that control local homeostasis and metabolism by engaging in intricate crosstalk with adipocytes and their precursors through secreted factors (adipokines). ... -
The role of liver myeloid cells in obesity and metabolic disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-11-24)Macrophages are tissue resident cells with diverse phenotypes and functions depending on their origin, localization and physiological context. In the liver, their main functions are to detoxify the blood from pathogens, ... -
Hereditary hypercholesterolemia and cardiovascular disease : functional and epidemiological aspects
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-11-20)Background. Individuals with familial hypercholesterolemia (FH) and/or high levels of lipoprotein(a) [Lp(a)] are genetically predisposed to develop early cardiovascular disease (CVD). We aimed to study the subclinical and ... -
Phenotyping of severe asthma in a clinical context
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-11-17)Severe asthma is a chronic heterogeneous inflammatory disease characterized by several clinical phenotypes and molecular endotypes. Although it affects a relatively small proportion of the asthma population (approximately ... -
Regulation of cytotoxic lymphocyte effector functions
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-11-06)Studies of patients with inborn errors of immunity provide an important opportunity to understand the human immune system in a natural context. The articles in this thesis are a compilation of such investigations. With ... -
Cellular and molecular mechanisms in the pathogenesis of irritable bowel syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-10-23)Irritable bowel syndrome (IBS) is part of the functional bowel disorder spectrum with no single accepted theory of its development and no biological marker for diagnosis. Today the diagnosis is defined by the ROME criteria, ... -
Novel vaccines and antiviral treatments for enterovirus induced infections and disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-10-16)Enterovirus infections are common around the world and can impact people’s lives in various ways, causing pancreatitis, myocarditis, common cold and more. This thesis is focused on testing the effectiveness of new vaccines ... -
Strategies to optimize natural killer cell functions in the tumor microenvironment
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-10-13)Immune cell-based therapies are currently changing the oncological treatment landscape worldwide. While genetically modified T cells have already been approved for clinical use in few hematological cancers, natural killer ... -
Improving prognostication for patients with myelodysplastic syndromes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-09-25)Background and aims: MDS constitute a heterogenous group of myeloid malignancies mainly characterized by dysfunctional hematopoiesis. Although cytopenia, dysplastic features and evidence of clonality are essential criteria ... -
Redox and epigenetic modulators regulate cardiac function and remodeling in health and disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-09-22)Oxidative species are a divergent group of cellular metabolites with a wide variety of functions. Together with reductants, they regulate almost all cellular functions, from mediating cellular communications to catalyzing ... -
Liver transplantation, cancer risk and comorbidity in acute porphyria
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-09-11)The porphyrias are a group of rare, mostly genetic, metabolic diseases caused by alterations in the eight enzymatic steps of the heme biosynthesis pathway. This thesis focuses on three of these diseases, acute intermittent ... -
Natural killer cell development and function in the context of allogenic stem cell transplantation and cell therapy
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-07-27)Natural killer (NK) cells play a crucial role in the control of viral infections and transformed, cancerous cells. These innate cells have high cytotoxic capacities and use a multitude of receptors to interact with ... -
Risk of hepatocellular carcinoma, liver-related complications, and death in persons living with chronic hepatitis B and D
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-07-21)Chronic hepatitis B virus (HBV) infection affects 257 million individuals and is a leading cause of liver-related morbidity and mortality. Hepatitis D virus (HDV) is a satellite virus, that needs HBV for packing and ...