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Recent submissions
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Evaluation of new and current preventive strategies for cervical and vaginal cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-05-08)This thesis addresses clinical research questions on primary and secondary prevention of cervical and vaginal cancer by targeting four groups of women in the organized cervical screening program; women entering the screening ... -
Epithelial alarmins as novel targets for treatment of asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-08)Asthma is a chronic obstructive airway disease characterised by episodic or chronic breathlessness due to recurrent bronchoconstriction, mucus production, airway inflammation and structural remodelling of the bronchi. ... -
Studies on obesity-related dysfunction in insulin-target tissues : insulin receptor isoforms and intraocular in vivo liver imaging
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Obesity, caused by poor dietary habits and sedentary lifestyle, has brought on a global health crisis. This condition affects over one-third of adults and largely increases the risk of developing metabolic diseases, such ... -
Prediction of mortality in hip fracture patients
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Background: Hip fractures are associated with elevated mortality and require extensive health care resources. As populations grow increasingly older the total amount of hip fractures has also escalated. An increasing amount ... -
Major lower extremity amputations : outcomes, complications, and patient perspectives
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-05-07)An amputation is considered to be one of the oldest surgical procedures; yet, despite advancements in medical care, it continues to be associated with high rates of complications and postoperative mortality. This thesis ... -
Delineating cell types and toxicity in human ovaries from birth to sexual maturity
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-05-06)The ovary contains the female germ cells known as oocytes, which are essential for female fertility. The immature oocytes reside within primordial follicles in the ovarian cortex and are referred to as the ovarian reserve. ... -
Pyrocarbon in shoulder hemi arthroplasty
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-05-03)Pyrolytic carbon, or pyrocarbon (PyC), has biocompatibility, a low friction coefficient and good wear resistance, making it a material of great potential for use in orthopaedics. PyC shoulder implants have shown promising ... -
Diet, genetic susceptibility, latent autoimmune diabetes in adults, type 1 and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-03)Diabetes is one of the most common chronic diseases, yet our understanding of modifiable risk factors remains incomplete. This project aimed to elucidate the role of diet in the risk of latent autoimmune diabetes in adults ... -
Hepatic diseases at the molecular level : identifying novel targets and biomarkers through transcriptomics
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2024-05-03)In the last few decades, the prevalence of obesity and metabolic diseases have dramatically increased and pose a major threat to global healthcare systems. The chronic excess of carbohydrates and fat is a risk factor for ... -
Mortality prediction and equity in emergency care
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-05-03)Introduction: Emergency departments (EDs) face crowding and long patient waiting times due to resource-demand imbalances. Waiting exposes patients to sufferings and risks, such as pain, anxiety, permanent organ damage, or ... -
Wearable neuromuscular electrical stimulation on quadriceps muscle can increase venous flow
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)Neuromuscular electrical stimulation (NMES) of the quadriceps (Q) may increase venous blood flow to reduce the risk of venous thromboembolism. This study assessed whether Q-NMES pants could increase peak venous velocity ... -
Residual substance P levels after capsaicin treatment correlate with tendon repair
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)The aim of the study was to assess healing after capsaicin-induced SP depletion during rat Achilles tendon repair by biomechanical testing. Capsaicin treatment reduced the concentrations of substance P (SP) by ~60% ... -
Prolonged immobilization compromises up-regulation of repair genes after tendon rupture in a rat model
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)It was hypothesized that mobilization versus immobilization after injury would promote tissue healing by regulating gene expression for molecules associated with repair. Cast immobilization versus free mobilization was ... -
High plantar force loading after Achilles tendon rupture repair with early functional mobilization
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)Background: Mechanical loading is essential for tendon healing and may explain variability in patient outcomes after Achilles tendon rupture (ATR) repair. However, there is no consensus regarding the optimal postoperative ... -
Knee extensor force production and discomfort during neuromuscular electrical stimulation of quadriceps with and without gluteal muscle co-stimulation
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)Purpose: To investigate whether Neuromuscular Electrical Stimulation (NMES) simultaneously applied on the quadriceps (Q) and gluteal (G) muscles, as compared to single Q-stimulation alters the knee extensor force production ... -
The effect of neuromuscular electrical stimulation on the human skeletal muscle transcriptome
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)Aim: The influence on acute skeletal muscle transcriptomics of neuromuscular electrical stimulation (NMES), as compared to established exercises, is poorly understood. We aimed to investigate the effects on global ... -
Impact of non-health sector determinants on child health the role of the Sustainable Development Goals : models, practices and perceptions in Cambodia and globally
(Inst för global folkhälsa / Dept of Global Public Health, 2024-05-02)Background. Child health has improved significantly over the last decades in Cambodia and globally. With the global adoption of the Sustainable Development Goals (SDGs) in 2015, a broad set of interlinked global goals to ... -
Surgical treatment of lung cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-02)Background: Surgery is a central part in the treatment of lung cancer. There have been recent advances in minimal invasive and lung sparing surgical techniques, but evidence regarding safety and implementability is not ... -
Automated microfluidic-based production of PET radioligands for clinical and preclinical use
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-05-02)In recent decades, microfluidic technologies have been explored for PET radiopharmaceutical production. Moreover, radiotracer production models have been gradually transitioning from centralized to decentralized models ... -
Sexual health in young adult survivors of childhood cancer : prevalence, predictors and web-based support
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-02)Aim: The overall aim of this thesis was to investigate the prevalence of sexual activity and dysfunction in young adult survivors (19-40 years) of childhood cancer in comparison to the general population. A further aim was ...