SwePub Export: Recent submissions
Now showing items 1-20 of 9974
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A problem-solving intervention for employees on sickness absence due to common mental disorders : effects, ethics and process
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)Purpose: Employees with common mental disorders (CMDs) which include depression, anxiety-, and adjustment disorder, are more often on sickness absence and have longer sickness absence episodes than employees with ... -
Omics-based immune profile in first-episode psychosis : revealing biomarkers for understanding schizophrenia pathophysiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-20)Schizophrenia is a lifelong, severe mental health disorder characterized by significant disability, disrupted psychosocial functioning, and premature mortality. Typically emerging in early adolescence, schizophrenia ... -
Prognostic factors in colorectal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-20)Prognosis in colorectal cancer (CRC) is largely stage dependent. Classification of disease stage is done according to the tumor, node, and metastasis-staging system (TNM). Disease stage often dictates treatment options ... -
“Should i stay, or should i go” : teachers’ motivation to stay at their workplace
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)The overarching aim of this thesis was to increase the knowledge on the relationship between teachers’ psychosocial work environment and teachers’ retention intention. This was done by exploring the psychosocial work factors ... -
Bone health impairment in childhood cancer : from preclinical studies to clinical insights
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-20)Survival outcomes in childhood cancer have significantly improved over recent decades. While this is a remarkable achievement, it has also led to a growing number of survivors who face a great risk of long-term morbidities. ... -
Studies on the modulation of gene expression via 3´UTR editing to model and treat neurological disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)It is increasingly clear that gene expression levels play a critical role in human health. For example, genome-wide association studies (GWAS) reveal that at least 93% of diseaseassociated changes are in non-coding ... -
The role of autophagy in Aβ and tau metabolism in Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)Alzheimer’s disease (AD) is characterized by amyloid plaques composed of amyloid beta (Aβ) peptides, and neurofibrillary tangles (NFTs) containing hyperphosphorylated and misfolded tau proteins. Aβ is generated ... -
Deciphering mechanisms that regulate aging in Caenorhabditis elegans
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-05-15)Aging is a multifaceted and poorly understood process characterized by physiological changes that culminate in the decline of an organism's functions. The research field of Biology of Aging aims to provide insight into ... -
Enhancing hospital care coordination : a resilience-centric approach to challenges and potential strategies
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2024-05-14)Background: The realms of patient flow management and care coordination, both aiming to optimize care delivery, are governed by distinct operational logics. Patient flow management is primarily a strategic tool concerned ... -
Clinical and radiological features of thoracic aortic disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-14)Background: The pathologies of the aorta constitute a group of severe diseases often managed by means of a single variable, the maximum aortic diameter. This variable is insufficient, and the aim of this work is to ... -
Decoding the symphony : illuminating the mammalian mitochondrial RNA binding proteome with a novel interactome approach
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-05-14)Mitochondria, colloquially known as the "powerhouses of the cell" are crucial for generating cellular energy through a process known as oxidative phosphorylation (OXPHOS). These minute but mighty organelles are distinct ... -
Biomarkers in hepatocellular carcinoma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-05-13)Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Globally in 2020, liver cancer were the seventh most common cancer form and the second most common form of cancer related death. Early HCCs are often ... -
Aspects on diabetes and diet with special focus on carbohydrates : epidemiological and clinical studies
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-13)Carbohydrate intake affects blood glucose levels more than any other dietary factor, providing a conceptually promising area of research in the prevention and management of diabetes. Intake of fruit and vegetables, a ... -
Evaluation of new and current preventive strategies for cervical and vaginal cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-05-08)This thesis addresses clinical research questions on primary and secondary prevention of cervical and vaginal cancer by targeting four groups of women in the organized cervical screening program; women entering the screening ... -
Epithelial alarmins as novel targets for treatment of asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-08)Asthma is a chronic obstructive airway disease characterised by episodic or chronic breathlessness due to recurrent bronchoconstriction, mucus production, airway inflammation and structural remodelling of the bronchi. ... -
Studies on obesity-related dysfunction in insulin-target tissues : insulin receptor isoforms and intraocular in vivo liver imaging
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Obesity, caused by poor dietary habits and sedentary lifestyle, has brought on a global health crisis. This condition affects over one-third of adults and largely increases the risk of developing metabolic diseases, such ... -
Prediction of mortality in hip fracture patients
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Background: Hip fractures are associated with elevated mortality and require extensive health care resources. As populations grow increasingly older the total amount of hip fractures has also escalated. An increasing amount ... -
Major lower extremity amputations : outcomes, complications, and patient perspectives
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-05-07)An amputation is considered to be one of the oldest surgical procedures; yet, despite advancements in medical care, it continues to be associated with high rates of complications and postoperative mortality. This thesis ... -
Delineating cell types and toxicity in human ovaries from birth to sexual maturity
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-05-06)The ovary contains the female germ cells known as oocytes, which are essential for female fertility. The immature oocytes reside within primordial follicles in the ovarian cortex and are referred to as the ovarian reserve. ... -
Pyrocarbon in shoulder hemi arthroplasty
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-05-03)Pyrolytic carbon, or pyrocarbon (PyC), has biocompatibility, a low friction coefficient and good wear resistance, making it a material of great potential for use in orthopaedics. PyC shoulder implants have shown promising ...